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Regular Modest Wine Drinking May Reduce Risk Of Second Heart
Attack September 3,
2002 DALLAS (American Heart Association) -- Middle-aged French men who drank two or more glasses of wine regularly after a recent heart attack were less likely to have a second heart attack or other cardiovascular complications compared to nondrinkers, according to a study in the rapid access issue of Circulation: Journal of the American Heart Association. The study examined data from the Lyon Diet Heart Study, a randomized trial
evaluating whether the Mediterranean diet may prevent further cardiovascular disease or
death after a first or recent heart attack. The impact of regular moderate alcohol consumption in patients with heart
disease is limited and controversial, says Michel de Lorgeril, M.D., the study's lead
researcher, at the Cardiovascular Stress and Associated Pathology Laboratory, at the
Joseph Fourier University of Grenoble, France. The Lyon trial offered a unique opportunity
to examine the issues in a very homogenous group of French middle-aged male survivors of a
recent heart attack. Researchers evaluated 353 men from the ages of 40 to 60 and classified the
amount of alcohol they routinely drank. There were no significant differences in the
severity of prior heart attack – the main indicator of new complications – in
medications used, or in the diet among the drinking ranges. During a mean follow-up of four years, 104 cardiovascular complications
(including recurrent heart attack, stroke and heart failure) occurred. Thirty six of the
complications occurred among men who abstained from alcohol; 34 among men who drank less
than two glasses of wine a day; 18 among those who drank about two glasses a day, and 16
among men who drank an average of four to five glasses of wine a day. Each glass of wine
was about four ounces, says de Lorgeril. Compared with nondrinkers, men who drank two or more glasses of wine each
day reduced their risk for a recurrent heart attack by more than 50 percent compared to
nondrinkers. The inverse relationship between wine drinking and the risk of
complication seemed to be independent of the major predictors of cardiovascular disease,
including smoking, cholesterol and blood pressure, as well as major lifestyle factors such
as dietary habits, says de Lorgeril. The researchers caution that it's too soon to make general recommendations
about secondary prevention. A great deal of prudence is required before extending the
results to other groups including women, people younger than 45, those older than 75, or
when considering other types of alcohol and drinking patterns, they say. More studies are
needed to better define the type of patients who would most benefit from moderate drinking
after a heart attack.
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